Research Technician (Part-time) - Molecular Biology and Bioinformatics

 Delaware State University is looking for a Research Technician (Part-time) in Molecular Biology and Bioinformatics to study microbiome and phage derived from various samples and its application using molecular biological techniques and bioinformatics.

 

Description

Delaware State University
Vacancy Announcement - Research Technician (Part-time)
Department of Human Ecology
Apply online at www.desu.edu
Applications will be accepted until position is filled

THIS IS A 100% GRANT FUNDED POSITION

The DNA Core is searching for a part-time Research Technician.  Responsibilities include but are not limited to: a motivated and ambitious candidate who wants to study microbiome and bacteriophage derived from various samples and its application using molecular biological techniques and bioinformatics. Collaboration with PD, Post-doc, and graduate students in conducting project and preparing manuscripts, proposals, and reports.

Qualifications

1. This position is open to PhD or MS. degree with an emphasis on Microbiology, Molecular Biology, Genomics, Bioinformatics or Biochemistry.

2. Candidates must have hands-on experience in molecular biological techniques (DNA extraction, DNA recombination/expression, Genbank, electrophoresis, Real-time PCR and conventional PCR assays including primer/probe design and copy number quantification, etc.)

3. Hands-on experiences in microbiological techniques (media preparations, cultivation, bacteria identification, managing bacterial and viral storage, spectrometry, aseptic techniques, etc.)  Bioinformatics and DNA sequencing experience will be plus.

4. Hands-on experiences in protein/enzyme works (protein purification, western blotting, enzyme assays, HPLC, FPLC/NGC) will be plus.

5. Effective oral and written communication skills.

6. Candidates must be willing to independently conduct research projects and collaborations with lab members.

 

To Apply:

Send a cover letter (including statements of research project experiences), CV, and contact information for three references to Dr. Samuel Besong, Search Committee Chair

 

Delaware State University is an equal opportunity, Title IX Employer and does not discriminate against persons on the basis of race, religion, national origin, sexual orientation, gender, marital status, age or disability.

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Research Assistant (Microbiology & Immunology) needed at National university of Singapore

 

Date: 12-Jun-2021

Location: Kent Ridge Campus, SG

Company: National University of Singapore

Job Description

The National University of Singapore invites applications for a Research Assistant position in the Department of Microbiology and Immunology, Yong Loo Lin School of Medicine. Appointments will be on a 1-year contract in the first instance, with the possibility of extension. 

Purpose of the post 
The Research Assistant will be responsible to, and work closely with the Principal Investigator and a team of researchers on the goals set out for the project(s) of interest. The project involves microbiology work with anaerobes and bacteriophages. 

Main duties and responsibilities  
The Research Assistant, under the supervision of the PI, is expected to:
-    plan and execute experiments in an independent manner.
-    Follow GLP and GDP to execute, document and report experiments.
-    Manage stocks and inventory and supervise orders and purchases.

Qualifications

Qualifications  
The applicant should:  
(a)    Hold BSc in Biological Sciences, or related disciplines.
(b)    Have knowledge and/or hand-on experience on microbiology (bacteriology and phage biology), anaerobic cultures and molecular biology.
(c)    Be able to work independently and in a team, and have an investigative nature & attention to details.
(d)    Knowledge of GLP and GDP is preferred.

Remuneration will be commensurate with the candidate’s qualifications and experience. 
Formal application: Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of 3 referees). 
  
We regret that only shortlisted candidates will be notified.  

Competencies

More Information

Location: Kent Ridge Campus

Organization: Yong Loo Lin School of Medicine

Department : Microbiology And Immunology

Employee Referral Eligible: No

More info here

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Microbiologist I/II – Quality Control needed at APHAGE

 

Position Description:  Microbiologist I/II – Quality Control

Exciting opportunity for an experienced microbiologist/phage biologist to join the upstream manufacturing team at Adaptive Phage Therapeutics (APT). In this position, the candidate will work alongside the upstream production team to perform QC testing of the therapeutic product per regulatory guidelines and/or SOPs including but not limited to: endotoxin quantification, HCP analysis, potency, visual inspection, and stability.

Major responsibilities:

• Grow bacterial batch culture and amplify bacteriophages in batch cultures including working with single use disposable bioreactor systems. 
• Perform in-process testing of material prior to releasing to downstream manufacturing team(s). 
• Propagate, maintain, and catalogue bacterial cell and bacteriophage lines used for manufacturing of the therapeutic drug product.
• Perform processes for the manufacture of the therapeutic product(s) under approved Standard Operating Procedures (SOPs).  
• Perform QC testing of the therapeutic product per regulatory guidelines and/or SOPs.
• Perform routine quality control review of manufacturing documents to comply with documentation practices outlined in the FDA’s guidance’s for Phase 1 GMP’s. These documents including but are not limited to: SOPs, Batch Records, Forms and third-party testing reports.
• Adhere to the company Quality Management System (QMS) to maintain highly controlled manufacturing processes. 
• Adhere to current Good Manufacturing Practices (cGMP), Good Documentation Practices (GDP), Biological Safety Level-2 (BSL-2), and aseptic technique in all Manufacturing/Laboratory processes.
• May help in the ongoing development of scale up batch culture processes.
• Must maintain a clean working environment including participation in regular laboratory cleaning schedule per established cleaning SOPs.
• Help provide oversight of day-to-day record-keeping, reporting and daily review according to cGMP guidelines.  
• Assist with document control of all active and retired Master documents according to the QMS.

Job requirements:

• BS in biology or related field.
• 1 – 3 years of experience in a laboratory setting, prefer experience in microbiology and/or bacteriophage biology.
• GMP experience preferred.
• Must be able to lift 40 lbs.
• Must be able to stand and work for extended periods of time.
• Will require scheduling flexibility to accommodate varying manufacturing schedules. Weekend shifts are also possible. 
• Outstanding organizational and communication skills.
• Ability to work independently and as part of a team
• Self-motivation, adaptability, and a positive attitude

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to HR@aphage.com

Job ID: 21.003

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Microbiologist I/II – Quality Control Testing

 

Position Description:  Microbiologist I/II – Quality Control Testing

Exciting opportunity for an experienced microbiologist/phage biologist to join the upstream manufacturing team at Adaptive Phage Therapeutics (APT). In this position, the candidate will support day-to-day operations to ensure timely and accurate testing of materials and products while maintaining quality and compliance to meet the demands of manufacturing.

Major responsibilities:

• Support manufacturing operations by; including but not limited to process validation, environmental monitoring, and utility systems sampling and testing.
• Receive, archive, and process clinical trial specimens according to company SOPs.
• Perform in-house microbiological assays for manufactured material and/or clinical trial samples.
• Prepare analytical lab reports or summaries as required within the necessary timeframe.
• Write, revise, and review SOPs for compliance with respective compendia, equipment operation, methods, and general laboratory procedures as needed.
• Perform in-process testing of material prior to releasing to downstream manufacturing team(s). 
• Perform processes for the manufacture of the therapeutic product(s) under approved Standard Operating Procedures (SOPs).  
• Adhere to the company Quality Management System (QMS) to maintain highly controlled manufacturing processes. 
• Adhere to current Good Manufacturing Practices (cGMP), Good Documentation Practices (GDP), Biological Safety Level-2 (BSL-2), and aseptic technique in all Manufacturing/Laboratory processes.
• Perform QC testing of the therapeutic product per regulatory guidelines and/or SOPs.
• Must maintain a clean working environment including participation in regular laboratory cleaning schedule per established cleaning SOPs.

• Perform routine quality control review of manufacturing documents to comply with documentation practices outlined in the FDA’s guidances for Phase 1 GMP’s. These documents including but are not limited to SOPs, Batch Records, Forms, and third-party testing reports. 
• Help provide oversight of day-to-day record-keeping, reporting, and daily review according to cGMP guidelines.  
• Assist with document control of all active and retired Master documents according to the QMS.

Job requirements:

• BS in biology or related field.
• 1 – 2 years of experience in a laboratory setting prefer experience in microbiology and/or bacteriophage biology.
• GMP experience preferred.
• Must be able to lift 40 lbs.
• Must be able to stand and work for extended periods of time.
• Will require scheduling flexibility to accommodate varying manufacturing schedules. Weekend shifts are also possible. 
• Outstanding organizational and communication skills.
• Ability to work independently and as part of a team
• Self-motivation, adaptability, and a positive attitude

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to HR@aphage.com

Job ID: 2020-006

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Next Generation Sequencing Technician needed by APHAGE

 

Position Description:  Next Generation Sequencing Technician

Exciting opportunity for a junior-level technician to learn Next Generation Sequencing (NGS) and join the Product Development team at Adaptive Phage Therapeutics (APT). The successful candidate will mainly be responsible for DNA extraction and purification from microbiological organisms but will also assist with DNA library preparation for NGS projects using Oxford Nanopore’s long-read sequencing platform. 

Major responsibilities:

• Follow Standard Operating Procedures (SOPs) and execute laboratory techniques which may include but are not limited to the following: cell culture, DNA extraction and purification, NGS DNA sequencing, PCR, gel electrophoresis, and other common microbiological and molecular biology techniques.
• Troubleshoot and adjust scientific methodology to correct problems or deficiencies as needed.
• Maintain careful laboratory records including written lab notebooks and well-organized digital data files.
• Manage laboratory supply inventory and report deficiencies to supervisor as needed.
• Adhere to all SOPs and project schedules set by supervisor(s).
• Provide daily project updates to supervisor(s).
• Coordinate efforts with data analysis teams as well as management ensuring the business needs are met.

Job requirements:

• Associate’s or Bachelor’s degree in Biology, Life Sciences, or a related discipline.
• One (1) year of academic or industrial laboratory experience (non-specific).
• One (1) year of previous bacterial cell culture and molecular biology laboratory experience is a plus, but not required.
• Demonstrated knowledge of maintaining accurate and detailed records.
• Demonstrated knowledge of proper laboratory disposal methods and safety procedures.
• Ability to adhere to the company Quality Management System (QMS) to maintain highly controlled manufacturing and quality processes.
• Adhere to current Good Manufacturing Practices (cGMP), Good Documentation Practices (GDP), Biological Safety Level-2 (BSL-2), and aseptic technique in all Manufacturing/Laboratory processes. 
• Must maintain a clean working environment including participation in a regular laboratory cleaning schedule per established cleaning Standard Operating Procedures.
• Cell culture and/or molecular laboratory experience is a plus.
• Careful, detail-oriented working style.
• Outstanding communication, collaboration, and problem-solving skills.

This full-time position reports to the Director, Product Development.

Compensation:  Salary is industry-standard and commensurate with experience.

To apply:  Please email cover letter and resume to HR@aphage.com

Job ID: 21.006

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Microbiologist I/II – Upstream Production needed at APHAGE

 Exciting opportunity for an experienced microbiologist/phage biologist to join the upstream manufacturing team at Adaptive Phage Therapeutics (APT). In this position, the candidate will work alongside the upstream production team to amplify bacteriophages on host bacterial cultures in mid-scale batches to be used in a clinical setting.

Major responsibilities:

• Grow bacterial batch culture and amplify bacteriophages in batch cultures including working with single-use disposable bioreactor systems.
• Perform in-process testing of material prior to releasing to downstream manufacturing team(s).
• Propagate, maintain, and catalog bacterial cell and bacteriophage lines used for manufacturing the therapeutic drug product.
• Perform processes for the manufacture of the therapeutic product(s) under approved Standard Operating Procedures (SOPs).
• Adhere to the company Quality Management System (QMS) to maintain highly controlled manufacturing processes.
• Adhere to current Good Manufacturing Practices (cGMP), Good Documentation Practices (GDP), Biological Safety Level-2 (BSL-2), and aseptic technique in all Manufacturing/Laboratory processes.
• May perform QC testing of the therapeutic product per regulatory guidelines and/or SOPs.
• May help in the ongoing development of scale-up batch culture processes.
• Must maintain a clean working environment including participation in regular laboratory cleaning schedule per established cleaning SOPs.

Job requirements:

• BS in biology or related field.
• 1 – 2 years of experience in a laboratory setting prefer experience in microbiology and/or bacteriophage biology.
• GMP experience preferred.
• Must be able to lift 40 lbs.
• Must be able to stand and work for extended periods of time.
• Will require scheduling flexibility to accommodate varying manufacturing schedules. Weekend shifts are also possible.
• Outstanding organizational and communication skills.
• Ability to work independently and as part of a team
• Self-motivation, adaptability, and a positive attitude

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to HR@aphage.com

Job ID: 2020-004

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Research Scientist or Engineer (Micro- and molecular biologist) needed

 At Eligo, we are passionate about developing new drugs to address unmet medical needs.

We are building a platform technology based on phage engineering to produce Eligobiotics to target a wide range of bacterial species. With such a capability, Eligo is poised to lead the new generation of precision microbiome engineering companies.

We are a six-year-old biotechnology company, spun out of MIT and Rockefeller University, and based in Paris, France. We have raised more than 20 million euros from leading investors in Silicon Valley and France to develop next-generation drugs addressing issues such as antibiotic resistance and diseases associated with the microbiome.

Eligo has been elected as one of the 30 Most Innovative Companies by the World Economic Forum, has received international awards for pioneering work in the field of synthetic biology, and has been featured in international media and scientific journals such as Nature Biotechnology, The New York Times, the BBC, The Economist, and Science.

Eligo has attracted top talent from all over the world, currently numbering over 40 Eligonauts from 10 countries, all driven, passionate, and motivated to impact the world by applying innovative research to save lives.

If you thrive in fast-paced environments, are excited to solve real-world problems with cutting-edge science, and are looking for an opportunity to develop your skills, we want to hear from you!

— YOUR MISSION —

As part of the Discovery team, you will strategically construct and characterize bacterial and phage collections that are associated with a wide range of diseases and then develop synthetic biology tools for these collections.

You will de-risk the technical aspects of potential novel targets by creating know-how and technologies for handling and genetically engineering bacteria and phages.

By leveraging your curiosity and eagerness to learn, you will be among the first researchers to have a shot at taming unexplored bacteria and phages. You will have the opportunity to oversee the progression of novel and promising targets from their initial assessment through the engineering and development pipelines. 

Your contributions will have a direct, tangible impact on the shaping of Eligo’s pipeline as projects arise and progress from the benchtop to the clinic!

— RESPONSIBILITIES —

• Strategically compose, assemble, characterize, and optimize benchtop protocols for isolation and building collections of bacteria and phage from complex patient samples
• Use synthetic biology techniques to engineer, test, and optimize strains, phages, and other genetic circuits
• Evaluate the potential of Eligo’s platform technology to address unmet needs in patients with microbiome-related diseases by conducting literature searches, communicating with KOLs, thinking critically, and developing a detailed overview on the challenges and opportunities.
• Play an integral role in research and development projects for promising indications once initial technical feasibility has been established

— REQUIREMENTS —

• Master’s in Microbiology or Molecular Biology or related field
  • Applicants with a Bachelor’s degree and several years of hands-on experience with a variety of bacteria will also be considered
  • Industry experience or Ph.D. is a plus
• Experience with handling, typing, and method development for fastidious bacteria, ideally including anaerobes
  • Experience with phages or other targeted killing methods of fastidious bacteria is a plus
• Demonstrated experience with state-of-the-art synthetic biology techniques (i.e. Gibson, MoClo or CRISPR, etc) in any type of organism is a plus
• Excellent communication skills in English
• Self-starter with strong attention to detail and accuracy, and ability to work independently to solve technical problems, keep a detailed up-to-date lab notebook, and an ability to multitask without compromising the quality of work
• Effective management of time and effort to meet deadlines 
  • Project management experience is a plus
• Strong interactive skills, collaborative attitude, and ability to work effectively in a team environment

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