Metaphore is seeking a Senior Scientist with expertise in recombinant DNA technologies, vector design, and phage/yeast/mammalian display systems. In this role, you will lead the design and generation of plasmid constructs, antibodies, protein libraries, and molecular display platforms to advance therapeutic discovery efforts
Vector Design & Molecular Cloning
- Design and construct expression vectors (plasmid/viral) for gene expression, knockdown, and editing.
- Apply traditional and high-throughput cloning techniques (e.g., Gibson Assembly, Golden Gate, Gateway).
Display Library Engineering
- Engineer phage, yeast, and mammalian display libraries (e.g., scFv, Fab, sdAb, and other related nanobodies).
- Develop and execute biopanning and affinity maturation strategies.
- Implement technologies such as deep mutational scanning (DMS) and massively parallel reporter assays (MPRA) to generate data for the company’s machine learning driven platform.
- Analyzing data using Python, R, and Linux-based bioinformatics tools.
Apply here
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