Metaphore is seeking a highly motivated, collaborative, and detail-oriented Senior Scientist with expertise in recombinant DNA technologies, vector design, and phage/yeast/mammalian display systems. Lead the design and generation of plasmid constructs, antibody/protein libraries, and molecular display platforms to advance therapeutic discovery efforts. The ideal candidate will thrive in a fast-paced, collaborative biotech environment and have experience with automation, high-throughput screening, and cloning.
Vector Design & Molecular Cloning
- Design and construct expression vectors (plasmid/viral) for gene expression, knockdown, and editing.
- Apply traditional and high-throughput cloning techniques (e.g., Gibson Assembly, Golden Gate, Gateway).
- Manage construct inventories using LIMS platforms (e.g., Benchling). Engineer phage, yeast, and mammalian display libraries (e.g., scFv, Fab, sdAb, and other related nanobodies).
- Develop and execute biopanning and affinity maturation strategies.
- Implement technologies such as deep mutational scanning (DMS) and massively parallel reporter assays (MPRA) to generate data for the company’s machine learning driven platform.
- Comfortable analyzing data using Python, R, and Linux-based bioinformatics tools.
Apply here
For more phage-related research and job opportunities, click here
