Genitourinary infections(GUI) are infections of the urinary or reproductive tracts. They can include urinary tract infections (UTIs), genital tract infections, and infections affecting the kidneys or perinephric space. Common examples include cystitis, pyelonephritis, prostatitis, urethritis, cervicitis, epididymitis, and pelvic inflammatory disease. The World Health Organisation’s(WHO) priority pathogens list highlights several organisms capable of causing common GUI infections within the high-priority groups.
Phages and their derived antimicrobial products are being employed to find new treatments for antimicrobial-resistant infections. The proposed PhD project seeks to develop new antimicrobials based upon whole phages and their derived antimicrobial enzymes. This will include the isolation and characterisation of novel phages from the environment using both phenotypic and genotypic methods, the development of recombinant expression systems suitable for continuous culture, and the evaluation of antimicrobial potential.
This studentship is fully funded for 3 years through the John Dawson Drug Discovery and Development Research Institute at the University of Sunderland
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