Focus on using cutting-edge science to unlock new approaches to treat people suffering from diseases with poor treatment options. Accelerate molecule discovery by building highly optimized foundational platforms, streamlining lab operations through advanced technologies, and investing in novel technologies and capabilities.
Lilly Small Molecule Discovery is seeking a pioneering Mammalian Display Scientist to build and optimize a mammalian cell surface display platform to uncover allosteric networks and cryptic binding pockets in challenging protein targets. This is a hands-on, lab-based position that establishes a cutting-edge discovery engine to support next-generation small-molecule drug development. The ideal candidate should have strong expertise in mammalian display technologies, protein engineering, and a passion for innovation at the interface of biology and chemistry.
Basic Requirements:
- Ph.D. in Molecular Biology, Protein Engineering, Cell Biology, Biochemistry, or a related field.
- Minimum of 3 years’ experience (industry or academic) developing or applying mammalian display systems, in an academic or industrial setting, supported by publications and/or patents
- Expert in saturation mutagenesis library generation.
- Experience with high-throughput screening methods, particularly FACS-based selections.
- Strong molecular biology skills, including cloning, mutagenesis, and protein engineering for stability and conformational control.
- Proficient in yeast or phage display
- Proven expertise in mammalian cell engineering (HEK293, CHO), including construct design, expression optimization, and surface display techniques.
Apply here https://careers.lilly.com/us/en/job/R-85991/Advisor-Sr-Advisor-Mammalian-Display?codes=Indeed
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