With expertise in cutting-edge proprietary technologies, Evercrisp is focused on tackling genetically validated, “difficult-to-drug” targets, particularly in areas of high unmet need where genetic medicines can create transformative outcomes. Seeking a highly motivated and ambitious protein engineer with a strong background in display technologies and molecular biology to advance miniprotein discovery projects.
Roles and Responsibilities
- Conduct miniprotein discovery and engineering campaigns with clear strategies and objectives.
- Partner closely with the Computational Biology team for in silico miniprotein library designs.
- Build phage and yeast display libraries using state-of-the-art molecular biology techniques.
- Help to establish a streamlined, validated workflow for miniprotein discovery by yeast and phage display.
- Develop and execute medium—to high-throughput screens using ELISA, flow cytometry/FACS, and other techniques to identify early hits.
- Characterize miniproteins using biophysical methods (e.g., BLI, DSF, DLS), to enable selection of leads.
- Analyze datasets from biophysical, analytical, and in vitro functional characterizations to prioritize top hits for downstream studies.
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