Responsibilities:
- Execute hands-on lab work and apply molecular biology, yeast/phage display, protein biochemistry, and rational protein engineering techniques to generate novel multi-specific therapeutics.
- Lead execution of protein engineering and antibody discovery/optimization efforts such as humanization, affinity maturation, specificity modulation, and platform improvements.
- Act as a Subject Matter Expert in Antibody Discovery and Engineering and guide the research project teams.
- Manage several projects simultaneously and act as a single point of accountability on projects.
- Collaborate with the structural biology and antibody production teams to develop and operationalize the discovery campaigns.
- Analyze and present data, both in written reports and oral presentations.
- Effectively manage projects and resources to maximize progress.
- Manage antibody discovery & optimization activities with the external CROs.
STAR0602 is Marengo’s lead program, the first selective T cell activator generated from Marengo’s STAR platform, a library of antibodies targeting non-clonal variable (V)ß regions of the TCR fused to different co-stimulatory moieties. STAR0602 is Marengo’s lead program, the first selective T cell activator generated from Marengo’s STAR platform, a library of antibodies targeting non-clonal variable (V)ß regions of the TCR fused to different co-stimulatory moieties.
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