To survive in the face of constant phage predation, bacteria have evolved diverse anti-phage defense systems that enable bacteria to detect and counter phage infections, including CRISPR-Cas systems, restriction-modification enzymes, and recently discovered novel phage defense systems such as Zorya.
This research project will focus on uncovering the molecular mechanisms underlying Zorya’s function and address key open questions, including how the host detects phage infection, how Zorya components are recruited to infection sites, and whether these mechanisms are conserved across Zorya subtypes. The project will integrate advanced techniques such as live-cell TIRF microscopy, super-resolution STED imaging, structure-based mutagenesis, and functional assays.
Please send your application (including a letter of motivation, CV, relevant certificates and contact details of 3 references) referencing the job ID DR/032/25 to Humboldt-Universität zu Berlin, Faculty of Life Sciences, Institute of Biology, Molekulare Mikrobiologie, Prof. Dr. Marc Erhardt (located: Philippstr. 13, Haus 22, 10115 Berlin), Unter den Linden 6, 10099 Berlin or preferably by e-mail in a single PDF file to jobs.molmicro@hu-berlin.de.
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