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Orchestration of microbial community function in the Preterm infant Gut by engineered phages

Survival of every preterm infant has significantly increased over the decades with advanced healthcare systems in place. However, necrotising enterocolitis (NEC) and late-onset sepsis (LOS) remain a major cause of death and disability in those born < 32 weeks of gestation. NEC and LOS together are now the commonest cause of death after the first week of life in preterm infants, and survivors suffer adverse physical and intellectual development. Despite their importance, NEC and LOS are poorly understood although both appear linked to an ‘imbalance’ in gut bacteria.

This research will use our bacterial model systems, experience in genomics, metabolomics, molecular biology, and phage biology, to implement an Engineering biology design-test-build-learn approach to altering bacterial community structure and function.

  1. A master’s degree or equivalent in microbiology, molecular biology or a related field.

    2. A genuine interest in scientific discovery.

3.  Experience in molecular biology, phage biology, microbiology, and bioinformatics is desirable.

4.   The ability to effectively communicate complex scientific concepts to diverse audiences.

5)     A collaborative mindset and the ability to work effectively within a multidisciplinary team.

Applications should be made by emailing needl@newcastle.ac.uk 

Details are here https://docs.google.com/document/d/1O76v8JZ3vAnH61zOpMFDIm16pryVPgaO/edit?tab=t.0

Apply here https://www.findaphd.com/phds/project/engineering-bacteriophages-orchestration-of-microbial-community-function-in-models-of-the-preterm-infant-gut/?p182905

For more phage-related research and job opportunities, click here https://jobs.thephage.xyz/

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