The MICRO-PATH Doctoral Training Unit (DTU) unites experts from various disciplines to investigate links between the microbiome and chronic diseases alongside generalizable pathogenic effects. Our mission is to understand these links causally and mechanistically and to establish the microbiome as a key target for future therapeutic and preventative measures.
The Luxembourg Institute of Science and Technology (LIST) is a Research and Technology Organization (RTO) active in the fields of materials, environment, and IT. By transforming scientific knowledge into technologies, smart data, and tools, LIST empowers citizens in their choices, public authorities in their decisions, and businesses in their strategies.
The gut resistome, i.e. all antibiotic resistance genes (ARGs) circulating in the gut, determines the microbiome dynamic, i.e. how an individual’s gut microbiome will respond to and recover from an antibiotic therapy. Moreover, the gut resistome is also a source of ARGs conferring antimicrobial resistance to virulent or clinically relevant strains. The horizontal gene transfer (HGT) between bacteria can occur in any environment and particularly when bacterial loads are high, like in the gut.
Notably, the gut microbiomes of diseased individuals are enriched in facultative pathogens that encode ARGs and might have an increased infective competence. A risk assessment of ARG excretion caused by gut dysbiosis will be established by combining data obtained about the frequency of ARG transfer events by transduction in case of gut dysbiosis and the survival of AMR bacteria in surface water as well as their competencies to transfer ARGs into the environment.
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