Looking for an enthusiastic and experienced research technician to join the Therapeutic Vulnerabilities in Solid Tumors and Sarcoma group of Dr Sophie Postel-Vinay and the Chromosomal Translocations group of Prof Terry Rabbitts. The exciting program is part of a new Fight Kids Cancer grant. It aims to develop and evaluate novel therapeutic approaches to target aggressive transcription factors-driven sarcomas of unmet needs of children and young adults, using notably degrader-based (PROTAC, small molecule or antibody) approaches.
The team has recently launched a program dedicated to desmoplastic small round cell tumors (driven by the EWS-WT1 transcription factor), which has so far mostly focused on molecular characterization (Hénon et al, Cell Rep Med 2024). This will build the foundations for this new program, which aims at adressing the challenge of targeting transcription factors and developing new therapies for patients, from bench to bedside.
The candidate should have a solid knowledge of molecular biology, protein chemistry and engineering, Ab structure, genome editing (CRISPR), molecular cloning, and cell culture. Experience in high-throughput screening using an antibody, phage display, small molecule or DNA-encoded libraries is desirable. The applicant works under the supervision of the PI, in close collaboration with other teams involved in the project at UCL, at The Institute of Cancer Research, and Gustave Roussy.
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