In this project, the student will carry out large-scale infection assays with diverse S. aureus isolates and phages to identify which phages are the most effective inhibitors of S. aureus growth, and find out why this is the case.
Mobile genetic elements (MGEs), such as phages and plasmids, play a key role in AMR dissemination but also offer a promising basis for non-antibiotic therapies. The activity of MGEs is fundamentally shaped by bacterial defenses, which can suppress AMR spread and limit the efficacy of phage-based therapies. Well-known bacterial defenses include Restriction-Modification (RM) and CRISPR-Cas.
Apply here https://www.exeter.ac.uk/study/funding/award/?id=5269
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