Apply and develop new genetic screenings (based on CRISPRi) to characterize phage genes that influence clinical efficacy against bacterial pathogens, characterizing them in their molecular context using interaction proteomics (affinity purification, proximity labeling, co-fractionation mass spectrometry) and engineered “superphages” that show increased efficacy against clinical isolates.
The Fossati lab investigates the composition and mechanism of the bacterial immune system using a combination of bulk NGS technologies and high-throughput interaction proteomics approaches (Fossati et al, 2023, Nat Com) as well as developing computational solutions to analyze next-generation interaction proteomics datasets using machine learning (Fossati et al, 2021, Nat Methods) and deep learning (Frommelt and Fossati et al, 2024, Nat Methods).
This is part of the KI-SciLifeLab Clinical Translational Postdoc Program to promote collaboration between SciLifeLab’s research environment and clinical research environments at Karolinska Institutet. The postdocs recruited to the program will be part of a network supported by the SciLifeLab Committee KI.
Apply here https://ki.varbi.com/se/what:login/jobID:754862/type:job/apply:1/
For more phage-related opportunities, click here https://jobs.thephage.xyz/
