This project will experimentally test whether clinical isolates from non-tuberculous mycobacterial infections collected from pulmonary sources, such as those acquired during biopsy or bronchiolar wash, from sputum, or from other sampled tissues contain evidence of bacteriophage(s).
Based on Oxford Nanopore sequencing performed in-lab, the student will perform genomic sequence analysis of the clinical isolates for signatures of prophage and will sequence all induced phage. Critically, this information analysis will investigate any genetic payload incorporated into the phage as a potential mechanism for the horizontal transfer of virulence determinates or disease-modulating genes.
This study will provide essential insight into the complex relationship between bacteriophages, their targets and human health.
Apply here https://le.ac.uk/study/research-degrees/research-subjects/respiratory-sciences
For more phage-related research opportunities, click here https://jobs.thephage.xyz/
